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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... #differential #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint Pain ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin ... #rashes #differential
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Disease Vaso-occlusive ... dz difficult to see ... • Differentiate ... from vaso-occlusive ... diagnosis #causes #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... 40, F:M 9:1 • Clinical ... , oral ulcers, Lupus ... #lupus #Systemic
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... Classification #Classes #differential ... #diagnosis #management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Erythematosus (SLE ... 40, F:M 9:1 • Clinical ... Usual therapeutic management ... rheumatology #diagnosis #management
Note there is ST depression in aVR, a true sign of Left Main occlusion.  Many
true sign of Left Main ... occlusion. ... occlusion. ... #Clinical #EM #IM ... #STElevations #STE
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... likely it will be clinically ... erythematosus (SLE ... (SLE), Systemic ... rheumatology #diagnosis #differential
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
Inflammatory joint pain ... and fingers, or pain ... the face (many differential ... children (pediatric SLE ... #diagnosis #sle
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Rheumatica • Pain ... temporal arteritis Inclusion ... Diffuse muscle pain ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential