11 results
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... dermatomyositis, SLE ... differential #diagnosis #dermatology ... #oncology #clinical ... #skin
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... areas -> Scaring alopecia ... inflammation on skin ... pathophysiology #diagnosis #signs
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Capitis - Skin ... Disease: Discoid lupus ... , Loose anagen syndrome ... Examination: • Signs ... Differential #Diagnosis #dermatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... and permanent alopecia ... Seizures • Strokes Skin ... • Nonscarring alopecia
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Most common extra cutaneous ... Episcleritis Signs ... - Lupus - Leukemia ... #diagnosis #dermatology ... #oncology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
vasculitis) • Cutaneous ... disease (SVC/IVC occlusion ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... thrombosis+Pulm HTN+skin ... to cold IgG • Lupus ... Differential #Diagnosis #Oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
aphthous ulcers, cutaneous ... such as systemic lupus ... reactions, and vaso-occlusive ... purpura: strong sign ... vasculitis, and SLE
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... Hepatomegaly • Skin ... diagnosis #workup #oncology ... #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... reactions, and vaso-occlusive ... purpura: Strong sign ... of cutaneous leukocytoclastic ... (lower legs), cutaneous