16 results
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... : CTD: SLE, RA related ... Disease • Cogan syndrome ... Vasculitis #skin ... #dermatology #rheumatology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... inflammation on skin ... Livedo Reticularis, Vasculitis ... diagnosis #signs #symptoms
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... most frequent skin ... dermatomyositis, SLE ... leukocytoclastic vasculitis ... differential #diagnosis #dermatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... and permanent alopecia ... • Nonscarring alopecia ... : • Symptoms limited
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Hypersensitivity vasculitis ... Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus ... Sarcoidosis #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
such as systemic lupus ... reactions, and vaso-occlusive ... Presentation - Systemic Symptoms ... strong sign of cutaneous ... , and SLE) • Urinalysis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
(SLE) General: ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... erythematosus #signs #symptoms
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... erythematosus (SLE
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... : • Vascular occlusion ... Kasabach-Merritt syndrome ... Associated - SLE ... #nonpalpable #dermatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
) • Cutaneous Lesions ... meningitis), MCC CNS symptoms ... disease (SVC/IVC occlusion ... Oral aphthae : SLE ... • Arthritis: SLE