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diagnosis rheumatology differential hairloss algorithm classification diffuse focal hematology purpura signs symptoms systemic ana anca antibodies antibody antineutrophil antinuclear aortitis
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus ... erythematosus ... #dermatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
erythematosus ... • Loose anagen syndrome ... - Secondary to Skin ... #dermatology #Differential ... Diagnosis #Algorithm #causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... and permanent alopecia ... Seizures • Strokes Skin ... • Nonscarring alopecia
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Capitis - Skin ... erythematosus, ... : Lupus erythematosus ... , Loose anagen syndrome ... Differential #Diagnosis #dermatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... areas -> Scaring alopecia ... hair follicles -> causes ... inflammation on skin ... Livedo Reticularis, Vasculitis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... : • Vascular occlusion ... Kasabach-Merritt syndrome ... Associated - SLE ... #nonpalpable #dermatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... ANCA associated vasculitis ... (RA), Systemic lupus ... erythematosus ( ... SLE), Sarcoidosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... : erythematous nodules ... erythematosus, ... reactions, and vaso-occlusive ... , and SLE) • Urinalysis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... #erythematosus #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... (e.g. systemic lupus ... erythematosus (
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