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hematology differential gammopathy rheumatology agglutinin algorithm anemia causes classification clinical cold complications diffuse disease erythematosus hemolytic leukemia lymphadenopathy paraproteinemias undetermined
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... Diagnosis Neurologic-Centered ... Cryoglobulinemia Renal-centered ... #Diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... to cold IgG • Lupus ... , retinal, DVT, ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Lupus Erythematosus ... Lymphocytes) - Monoclonal ... Lymphadenopathy #LAD ... #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
of Undetermined Significance ... constitutional symptoms ... hyperCalcemia, Renal ... #hematology #diagnosis ... #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Monoclonal IgM ... of undetermined significance ... (MGUS), CLL, Myeloma ... hemolytic #anemia #hematology ... #diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
of Undetermined Significance ... treatment of infective symptoms ... ; vaccinations Renal ... Complications #diagnosis ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... APLA/LAC: • Renal ... : • Symptoms limited ... #Systemic #Lupus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... • Auer Rods Significant ... translocation • Significant ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... Symptoms (Sx) in ... retinopathy Lab ... vasculitis, and SLE
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