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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... venn #nephrology #nephritis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Arthritis: • Joint ... arthropathy • 90% joints ... (nephrotic-range ... APLA/LAC: • Renal
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
of Membranous Lupus ... SLE 4. ... for worsening disease ... SLE • Calcineurin ... #Membranous #Lupus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... nephritis, NPSLE ... • Immunologic Workup ... Evolution: Chronic disease
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Arthritis R Renal ... Disease (Nephritis ... #IMDAMNSHARP #sle ... #systemic #lupus
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
in at least 2 joints ... hemolysis • Renal ... nephritis, Class ... nephritis Immunologic ... Classification #Criteria #SLE
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
), RA, crystal disease ... spondyloarthropathies, lupus ... Inflammatory, crystalline disease ... Chronic = RA, SLE ... rheumatology #approach #workup
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Malar rash • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
Lupus Nephritis ... approach to kidney disease ... with systemic lupus ... Non-LN Kidney Disease ... (5%) #Lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... • Immunologic Workup ... nephritis, NPSLE ... • Immunologic Workup ... Evolution: Chronic disease