15 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Malar rash • SLE ... IBD • RA • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
lymphocytic lymphoma (SLL ... -> Invade Skin: ... Lymphocytic Lymphoma (SLL ... /SLL into a significantly ... #Leukemia #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... (SLE) General: ... Sjögrens (15%) Skin ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
incompetent • CLL ... non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... Hepatomegaly • Skin ... workup #oncology #hematology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... UV light Incr cell ... inflammation on skin ... #SLE #Mucocutaneous ... pathophysiology #diagnosis #signs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Erythematosus #Diagnosis #Rheumatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm
Erythrematous or violaceous papules & plaques with overlying scale
 •
Papulosquamous Skin ... Auspitz sign, Koebner's ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #dermatology #Differential
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Pain in Sickle Cell ... dz difficult to see ... • Hematogenous ... diagnosis #causes #hematology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Syndrome) is a skin ... Episcleritis Signs ... general feeling of ill ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... ulcerations • Skin ... CD4+ and CD8+ T cell ... Dermatomyositis #rheumatology ... #dermatology #diagnosis