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diagnosis differential hematology oncology rheumatology causes leukemia pain symptoms algorithm bone chronic classification cll disease erythematosus lymphocytic manifestations mucocutaneous papulosquamous
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... Malar rash • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: ... Sjögrens (15%) Skin ... #SLE #systemic ... erythematosus #signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... inflammation on skin ... #SLE #Mucocutaneous ... pathophysiology #diagnosis #signs ... #symptoms #complications
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... other orthopedic complications ... dz difficult to see ... • Hematogenous ... diagnosis #causes #hematology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin ... Auspitz sign, Koebner's ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #dermatology #Differential
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
inflammation of the joints ... Episcleritis Signs ... and pain of the joints ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... Hepatomegaly • Skin ... kinase (BTK) Complications ... leukemia • GI complications
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... vesicular eruption - Joints ... such as systemic lupus ... purpura: strong sign ... vasculitis, and SLE
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
bone pain, fever, joint ... lymphocytic lymphoma (SLL ... CLL -> Invade Skin ... Transformation: • Complication ... #Leukemia #Hematology
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