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diagnosis rheumatology differential causes hematology management classification erythematosus oncology symptoms activation anca antibodies antibody antineutrophil aortitis behcet bruising chronic cll
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... , Purpura, Urticaria ... #SLE #systemic ... erythematosus #signs
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Non-blanchable, dark red ... Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... Associated - SLE ... #nonpalpable #dermatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... cases • Sjögren syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... • Cogan Syndrome ... lupus erythematosus ... : strong sign of ... , and SLE) • Urinalysis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... diseases: - 10% SLE ... disorder (e.g. systemic ... lupus erythematosus ... (SLE), rheumatoid
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... (lupus, RA, Sjogren's ... for hepatitis B and ... Measurement of antinuclear ... #Causes #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... : Strong sign of ... Skin lesions (red ... • Behcet syndrome ... • Cogan syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... Female • Peaks 3rd ... vasculitis, rheumatoid ... #Systemic #Lupus
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... easy bruising to purpura ... (Petechial or purpuric ... lupus erythematosus ... [SLE], AOSD) •
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Disease (IgG4-RD ... Arthritis (RA), Systemic ... lupus erythematosus ... (SLE), Sarcoidosis
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