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diagnosis rheumatology differential algorithm ana antibodies antibody antineutrophil antinuclear aortitis cryoglobulinemia cryoglobulins diseases erythematosus hematology inflammatory management nonpalpable orthopedics palpable
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... • Sjögren syndrome ... Vasculitis: •
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... , and SLE) • Urinalysis ... #rheumatology #classification
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... Disease (IgG4-RD ... Arthritis (RA), Systemic ... lupus erythematosus ... (SLE), Sarcoidosis
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Arthritis • Systemic ... Lupus Erythematosus ... #Inflammatory #JointPain ... #MSK #Differential ... #Orthopedics #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... diagnosis #types #classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Non-blanchable, dark red ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... , Sjogren's ... #nonpalpable #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... Skin Disease Classification ... dermatomyositis, Sjogren ... #Systemic #Lupus
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Vasculitis: • ... phenomenon (16%) MSK ... Biologic: 2nd or 3rd
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