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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupus Erythematosus ... Renal #diseases #SLE ... #Systemic #Lupus ... nephrology #nephritis #classification ... #types #rheumatology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... - Red blood cell ... arthritis, and systemic ... lupus erythematosus ... #Classification
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
bite, Migratory red ... Arthritis • Systemic ... Lupus Erythematosus ... #Inflammatory #JointPain ... #MSK #Differential
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... diseases: - 10% SLE ... lupus erythematosus ... (SLE), rheumatoid ... #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... Skin Disease Classification ... Kikuchi disease • Type-I ... #Systemic #Lupus
Types of Melanoma
Superficial Spreading
 • Most common form
 • Often develops in previously benign mole
 •
Types of Melanoma ... black/blue or pink/red ... eye you cannot see ... differential #diagnosis #classification ... #dermatology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
heat and looks red ... is oftentimes systemic ... Rheumatoid arthritis, Lupus ... Comparison #Versus #MSK ... #JointDisease #JointPain
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... such as certain types ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... IV RTA, TYPE I ... Central nervous system ... phenomenon (16%) MSK ... Biologic: 2nd or 3rd
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Hereditary defects in red ... lupus erythematosus ... (SLE), sickle cell ... Pseudohypoaldosteronism type ... High #Potassium #Classification