9 results
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
Renal involvement ... in Systemic Lupus ... #lupus #nephritis ... #SLE #Systemic ... #management #treatment
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... APLA/LAC: • Renal ... Chronic B-cell activation ... #Systemic #Lupus
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
at least 50% Renal ... • Hepatorenal syndromes ... Drugs • Emboli Systemic ... Acute Interstitial Nephritis ... Sjögren) Post-Renal
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... block • Sjogren syndrome ... #Lupus #Erythematosus ... #rheumatology #management
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... inhibitors, hepatorenal syndrome ... Secondary GNs: Due to systemic ... Post-infectious GN, Lupus ... Acute Interstitial Nephritis
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... discoloration) • Chronic renal ... discoloration) • Nephrotic ... syndrome #NailDisorders ... #dermatology #Differential
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... #Management #Hematology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... cirrhosis: 3%-20% Renal ... • Interstitial nephritis ... Distal (Type I) renal ... Rheumatology #Diagnosis #Management
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Hereditary defects in red ... lupus erythematosus ... (SLE), sickle cell ... Tubulointerstitial diseases: SLE ... antiphospholipid syndrome