20 results
Etiology of Splenic Infarction:
 • Hypercoagulability: Factor V Leiden, Antiphospholipid syndrome, Malignancy
 • Embolic disease: Atrial
Etiology of Splenic ... Infarction: • ... endocarditis • Trauma ... compression • Splenic ... differential #diagnosis #causes
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
deficiency) • Infection ... rheumatologic, trauma ... Post-splenectomy or Asplenia ... Differential #Diagnosis #causes ... #Platelets #hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm
Infection
 • Bacterial
 • Abscess
 • Viral
Medications
Causes of Neutrophilia ... Diagnosis Algorithm Infection ... disorders • Asplenia ... Diagnosis #Algorithm #Causes ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... burns, Myocardial infarction ... , Severe trauma, ... period • Others: Asplenia
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
neuropathy so trauma ... with bacterial infection ... infection. ... Like in this case ... #rheumatology #
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Common d/t impaired splenic ... BrighamChiefs #Bone #Joint ... differential #diagnosis #causes ... #hematology
Causes of Splenic Infarcts - Differential Diagnosis
 • Myeloid disorders: Myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential
Causes of Splenic ... splenomegaly • Trauma ... Wandering spleen • Infection ... Cytomegalovirus, Malaria #Splenic ... #Infarction #Differential
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... infiltration: malignancy, infection ... , endocarditis Splenic ... Diagnosis #Framework #hematology
Capnocytophaga Canimorsus Skin Rash

40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
dogs & latter can cause ... underlying r.f as asplenia ... C. canimorsus infection ... Capnocytophaga infection ... patients who are asplenic
Endocarditis checklist
Initial evaluation
 • Peripheral blood cultures (three sets at three different sites)
 • Additional culture
for metastatic infection ... (e.g., spine, joints ... • Aggressive management ... metastatic foci of infection ... septic arthritis, splenic