21 results
Algorithm for Diagnosis of the Petechial / Purpuric Rash

Febrile/Toxic, Palpable: 
 - Meningococcaemia, Disseminated Gonococcal Infection,
Algorithm for Diagnosis ... Purpura Fulminans, DIC ... , Thrombotic Thrombocytopaenic ... Purpura #Rash #Algorithm ... #Diagnosis #Dermatology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Approach to Thrombotic ... and Management Algorithm ... TMA: Unexplained thrombocytopenia ... Reticulocytes, smear ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... ITP • SLE • CLL ... • TTP/HUS • DIC ... #Causes #Hematology
Approach to suspected Heparin-Induced Thrombocytopenia (HIT)

 • Suspected HIT Algorithm
 • "4 T's" clinical probability score:
Suspected HIT Algorithm ... • "4 T's" clinical ... - Thrombosis ... #HIT #hematology ... diagnosis #4Ts #algorithm
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... DIC, TTP, HUS) ... cells: Sickle cell ... #Analysis #hematology ... interpretation #clinical
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... • Peripheral smear ... - bleeding or thrombosis ... presence of large thrombosis ... treatment #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... infiltrates (anemia, thrombocytopenia ... • Peripheral smear ... Fibrinolysis & DIC ... #Leukemia #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
hemolysis: • Thrombotic ... hemolytic-uremic syndrome (ST-HUS ... organ or stem cell ... transplant • DIC ... differential #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation (DIC ... syndrome - Thrombotic ... thrombocytopenic ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... non-specific red cell ... arrow) Peripheral smear ... hemolytic #anemia #Hematology ... #Pathology #Smear