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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... In Systemic Lupus ... Erythematosus #SLE #hematology ... differential #diagnosis ... #causes
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... - Differential Diagnosis ... artery aneurysm: Causes ... compression and DVT ... #clots #hematology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin Rash ... • Bullous systemic ... Vesiculobullous #SkinRash ... #dermatology #Differential ... #causes
Reactive Skin Rash - Differential Diagnosis Algorithm
Reactive erythematous with various morphology
 • Urticaria - Firm /
Reactive Skin Rash ... - Differential Diagnosis ... #Reactive #SkinRash ... #dermatology #Differential ... #causes
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... hemolysis: • Thrombotic ... hemolytic-uremic syndrome (ST-HUS ... macroangiopathic hemolytic anemia ... #hematology #hemolysis
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
• Bleomycin Hematologic ... • Sickle Cell Anemia ... Ulcers #ulcerative #skinrash ... #dermatology #Differential ... #causes
Pustular Skin Rash - Differential Diagnosis Algorithm
Pruritic / Scaly / Erythematous lesions, usually poorly demarcated
Acneiform -
Pustular Skin Rash ... - Differential Diagnosis ... #Pustular #SkinRash ... #dermatology #Differential ... #causes
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Iron deficiency anemia ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Causes of Breakthrough/Extension of Thrombosis and Management Algorithm

#Anticoagulation #Breakthrough #Thrombosis #Algorithm #Extension #VTE #DVT #Hematology #Management
Causes of Breakthrough ... Extension #VTE #DVT ... #Hematology #Management ... #Diagnosis #Differential ... #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... syndrome - Thrombotic ... microangiopathy: Thrombotic ... #hematology #anemia