1771 results
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
and glutathione synthesis ... deficiency) • Liver ... organic acid screen Treatment ... diagnosis #management #treatment
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
DIC • Severe Liver ... : - Impaired synthesis ... + Bleeding Treatment ... diagnosis #causes #treatment
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Metabolism Synthesis ... Pathophysiology #Functions #Liver ... #Hepatology #Synthesis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... In liver, 80% of ... phosphatase: • Synthesis ... due to increased synthesis ... clearance - AP synthesis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Causes of Acute Liver ... salts augment synthesis ... ALP - Due to synthesis ... source - Tests of synthetic
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Identify Acute Liver ... - Specific to liver ... salts augment synthesis ... ALP - Due to synthesis
Pharmaceutical Management of Hyperthyroidism / Thyroid Storm
Beta-Blockers 
• Decreases sympathetic hyperactivity 
• Partially blocks peripheral conversion
PTU) • Blocks synthesis ... Methimazole • Blocks synthesis ... Administer only after synthetic
Antibiotic Classification by Mechanism of Action

Cell Wall Synthesis: 
Penicillins 
Cephalosporins 
Carbapenems 
Monobactams 
Beta-lactamase inhibitors
Glycopeptides 

 Protein
Action Cell Wall Synthesis ... Glycopeptides Protein Synthesis ... Folic Acid Synthesis ... Metronidazole mRNA Synthesis
Antibiotic classification refers to the categorization of antibiotics based on their chemical structure, mechanism of action,
Cell wall synthesis ... Protein synthesis ... DNA synthesis inhibitors ... RNA synthesis inhibitors ... Imagine treatments
Antibiotics - Mechanisms and Sites of Action 

Inhibit Cell Wall Synthesis or Function 
- Beta Lactams,
Inhibit Cell Wall Synthesis ... Inhibit Protein Synthesis ... Inhibit Protein Synthesis ... Inhibit Nucleic Acid Synthesis ... Inhibits Folate Synthesis