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Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 • Direct lesion contact during sex is responsible
Syphilis - Clinical ... Treatment 1) Primary ... after initial infection ... 30 years after primary ... Treatment: • Primary
Primary Syphilis
Usually, a single ulcer (chancre) appears at the site where the bacteria entered the body.
Primary Syphilis ... syphilis usually ... administered, the infection ... #Primary #Syphilis ... Chancres #Diagnosis #Clinical
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
encephalitis, and primary ... should be based on clinical ... specificity 90–100% Primary ... approaching 100% for primary ... in HIV: • CNS Syphilis
Natural History of Syphilis
Primary - 2-6 weeks after infection
 • Chancre, Regional lymphadenopathy
Early Latent ≤ 1
Primary - 2-6 weeks ... after infection ... ≤ 1 year after infection ... 2 months after primary ... > 1 year after infection
Syphilis Staging - Primary, Secondary, Latent and Tertiary - Timing and Features

Primary syphilis classically presents with
Syphilis Staging ... - Primary, Secondary ... Secondary syphilis ... infection and late ... infection.
Causes of Encephalopathy - Differential Diagnosis Algorithm
Hyperacute:
 - Primary Neurologic: Vascular (IS, ICH), Seizure, Migraine, Trauma
Hyperacute: - Primary ... demyelination), Infectious ... Subacute: - Primary ... Chronic: - Primary ... (syphilis, HIV-associated
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Primary Syphilis ... the hallmark of primary ... to asymptomatic infection ... the period of primary ... Comprehensive Review of Infectious
Treatment Recommendations for Syphilis in Non-Pregnant Adults by Syphilis Stage

Incubating Infection, Primary, Secondary, Early Latent Syphilis:
Incubating Infection ... , Primary, Secondary ... consultation with an infectious ... Testing for HIV infection ... CDC2015 #Regimen #Primary
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... • Common clinical ... • In tertiary syphilis ... can present with primarily ... rav7ks #CNS #Infections
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
Infectious Joint ... Disseminated Gonoccocal Infection ... • Secondary Syphilis ... like rash) • Primary ... HIV Infection