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diagnosis rheumatology biliary differential hepatology management sjogrens agglutinin anemia antibodies associations autoantibodies classification cold cryofibrinogenemia disease diseases erythematosus hemolytic lupus
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Algorithm Symptoms ... #PBC #Primary ... #hepatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
biliary cirrhosis ... (PBC), or with ... (SLE) Signs / Symptoms ... - Decreased tear ... Diagnosis #Signs #Symptoms
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, Anti-gp210 - Primary ... biliary cirrhosis ... (PBC) Anticentromere ... disease c-ANCA - Vasculitis ... diagnosis #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... • Cogan Syndrome ... well as inner ear ... Presentation - Systemic Symptoms ... Lab Tests: • CBC
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... with GCA or as primary ... Rash, arthritis Primary ... • Progressive symptoms ... • Cogan syndrome
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... Cirrhosis - Management ... Manage symptoms ... complex: Artificial tears ... survey disease #PBC
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... 15% of AIHA Primary ... Cold Agglutinin Syndrome ... Blood smear - RBC ... hemolytic #anemia #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
) • Cutaneous vasculitis ... biliary cirrhosis ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis ... Symptomatic: artificial tears
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Malignancy (e.g. hematologic ... the context of primary ... • Mesenteric vasculitis ... Induced Lupus: • Symptoms
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... Primary (essential ... malignancies, vasculitis ... Antiphospholipid syndrome ... #hematology
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