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diagnosis hepatology lfts transaminitis hepatitis abnormal acidosis causes chemistry classification drug enzymes function functiontest gastroenterology hepatocellular idiosyncratic induced interpretation lactate
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... extrahepatic source - Tests ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... abnormality vs bone Bili ... Hepatocellular injury ... 2: Cholestatic injury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... test abnormalities ... Injury Differential ... #Injury #Differential
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... magnitude of enzyme elevation ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver ... #Enzymes #Differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... or renal injury ... or diagnostic tests ... Injury: • Reduced ... #Differential #
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