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diagnosis lupus erythematosus sle hematology table treatment activation ana antinuclear autoimmune behcet cerebritis chronic cll cns comparison differential druginduced igg4
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... the formation of autoantibodies ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... highly inflammatory disease ... Liver function tests ... #Diagnosis #Management ... #Hematology #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
female, asian • Systemic ... specific laboratory tests ... #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... Positive pathergy test ... is a skin prick test ... #diagnosis #management ... signs #symptoms #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... clinically suspected, tests ... SLE-SSc-AlM overlap syndromes ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months) and of autoantibodies ... months to years) Systemic ... Evolution: Chronic disease ... comparison #table #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... adults in the west ... cells can indicate disease ... ’s CLL Scoring system ... Leukemia #diagnosis #workup
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Diagnostic Tests ... RP-ILD), dermato-rheumatologic ... Mechanic's hands Autoantibodies ... • Conduction system ... Myositis #Myopathy #rheumatology
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