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differential algorithm causes oncology management testing atlas hemolysis morphology rheumatology agglutinin arthritis blood bloodcell chronic classification cll cold disorders elevatedmcv
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... PD deficiency, Pulmonary ... thrombocytopenia (ITP ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... (sometimes) Macrocytic ... Microangiopathic Hemolytic ... #differential #diagnosis ... #hematology #microscopy
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... for degree of anemia ... #Algorithm #Diagnosis ... #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential Diagnosis ... RBCs, DAT (-) → ... malignancy, autoimmune disease ... anemia (TTP, HUS
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... , CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... Non-megaloblastic: Liver disease ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... thrombocytopenia - DIC, TTP ... #Anemia #Differential ... #workup #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Neutrophils - Low RBC ... RBCs in Rouleaux ... #Macrocytic ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Fragmentation - MAHA: TTP ... Defects: Sickle cell anemia ... Laboratory Tests ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... thrombocytopenic purpura (TTP ... • Intrinsic RBC ... #hematology #anemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... hallmark for the disease ... value is low, tests ... anemia Indirect ... #Workup #Hematology
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