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clinical diagnosis pocus thrombus cardiology echocardiogram hematology differential management a4c ultrasound atrial causes pathophysiology anticoagulation pharmacology algorithm pulmonary embolism laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... • Elevation in thrombin ... → thrormbin-induced ... consumption of coagulation ... Intravascular #Coagulation
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... @DharSaty #coagulation ... xarelto #DOAC #vWF #thrombin
Coagulation Cascade - Actions of Anticoagulants • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin • Fondaparinux • Direct
Coagulation Cascade ... Warfarin • Direct Thrombin ... EricsMedicalLectures/ #Coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... FVa to generate thrombin ... Thrombin, then primes ... #Coagulation #Cascade ... #platelet #thrombin
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
commonly used anti-coagulation ... rivaroxaban - Direct thrombin
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Anticoagulants on Coagulation ... Clotting Time, Thrombin
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... inhibitors, direct thrombin ... EricsMedicalLectures/ #Coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation ... • Increased thrombin ... is simultaneous coagulation ... cause • Correct coagulation ... Intravascular #Coagulation
Thromboelastogram Interpretation Reaction Time (R Value): - Time till initiation of fibrin clot - Treatment: FFP, protamine K
assay representing thrombin-platelet ... Thromboelastography #diagnosis #coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
or percreta) Thrombin ... intravascular coagulation ... (DIC) • Anti-coagulation
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