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diagnosis management differential algorithm oncology causes rheumatology chronic liver acute anemia comparison dermatology druginduced hemolysis injury leukemia lupus lymphocytic pharmacology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... For most indications ... #pharmacology #treatment ... #medications #table ... decisionaid #cardiology #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
, PCH, Evans Syndrome ... Membrane Defects, Drugs ... , Liver Disease, ... Defects: Sickle cell ... Differential #Diagnosis #hematology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Toxic: Alcohol, Medication ... , Recreational Drugs ... obstruction, HELLP Syndrome ... , Sickle Cell, VOD ... Acute #algorithm #hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... Diagnosis #Algorithm #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... infection) - Drugs ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... microglobulin Treatment ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... workup #oncology #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... duration), Several medications ... /HDS treatments ... Alcohol-related liver disease ... Diagnosis #Algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
in those with CLD ... months without treatment ... underlying liver disease ... Hepatitis (AAH) Drug-Induced ... Failure #Cirrhosis #Hepatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... chemotherapy for low-risk disease ... • Indications ... uw_IMresidency #CLL ... Leukemia #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
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