22 results
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic ... Myeloid Leukemia ... Differential #Diagnosis #causes ... #Platelets #hematology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... features in most cases ... promyelocytic #leukemia ... APML #Pathology #Hematology ... #Clinical #Smear
Hypersegmented neutrophil in a case of acute myeloid leukemia.

Dysplastic neutrophils are typically hypolobated but can be
neutrophil in a case ... acute myeloid leukemia ... AML #Clinical #Hematology ... #Pathology #Smear
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... Chronic leukemia ... -> AML: Blast crises ... • Peripheral smear ... #Hematology #Oncology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm
Infection
 • Bacterial
 • Abscess
 • Viral
Medications
Causes of Neutrophilia ... Myeloproliferative Disorder • Chronic ... myelogenous leukemia ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Age > 50 • Chronic ... Lymphocytic Leukemia ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Polycythemia Vera • Chronic ... Myelogenous Leukemia ... : • Acute or Chronic ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... myeloid leukemia ... #hematology #secondary
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Normochromic RBCs on Smear ... • Chronic Bleed ... Spherocytes on Smear ... Diagnosis #Algorithm #Causes ... #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Disorders: • Chronic ... myeloid leukemia ... Chickenpox Other Causes ... Differential #Diagnosis #causes ... #hematology #basophils