42 results
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Autoantibodies to vWF ... Autoimmune disease • vWF ... #Acquired #vonWillebrand
Factor VIII synthesis - Normal, Haemophilia A and Von Willebrand Disease

Normal - vWF carrier protein protects
Disease Normal - vWF ... the absence of vWF ... #HaemophiliaA #VonWillebrand
Von Willebrand Disease Classification
Type 1 (Accounts for ~3/4 of cases):
 • Defect: Quantitative defect (i.e. not
i.e. not enough VWF ... dysfunctional VWF ... total absence of vWF ... EricsMedicalLectures/ #VonWillebrand
Approach to Von Willebrand disease (VWD)

By Matthew Ho, MD PhD @MatthewHoMD

#VWD #Von #Willebrand #VonWillebrand #disease #hematology
Willebrand disease (VWD ... MatthewHoMD #VWD ... Von #Willebrand #VonWillebrand
Von Willebrand Disease - Clinical Presentation, Diagnosis and Management

- Dr. Eric Strong @DrEricStrong - Strong Medicine
EricsMedicalLectures/ #VonWillebrand
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Diagnosis VWF ... (Quantity of VWF ... considered to be low) VWF ... of this plasma VWF ... (differentiate VWD
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
xarelto #DOAC #vWF
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
also be seen in vWD ... differentiate vWD ... BS by measuring vWF
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Desmopressin (DDAVP) #VonWillebrand
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
of GP Ib/IX/V [vWF ... α-granules (contains vWF