Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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differential causes hepatitis management acquired antibodies associations atlas autoantibodies bloodcell calculation coagulation comparison deficiencies deficiency diseases extravascular hemolysis hemolytic hepatorenal
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g ... IgM) (e.g. primary ... deficiencies (e.g ... Membrane defects (e.g ... #hematology #anemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... inflammatory disorders (e.g ... . autoimmune, TB ... Myelodysplastic syndrome ... #Causes #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... disorders (e.g. ... #comparison #diagnosis ... #hematology #deficiency
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... Intrinsic RBC defects (e.g ... Production #Index #hematology ... #diagnosis #calculation
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
- Diagnosis and ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... thrombocythemia), Autoimmune ... #treatment #hematology
Hyponatremia - Differential Diagnosis by Mechanism Decr Blood Pressure (“Decr Effective Circulating Volume”) - Volume depletion
- Cirrhosis Syndrome ... - Malignancy (e.g ... CNS pathology (e.g ... pathology (e.g. ... #Table #Causes
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... #differential #diagnosis ... #hematology #microscopy
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... - Vasculitis, e.g ... - Vasculitis, e.g ... Associations #diseases #diagnosis ... #table #rheumatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... ischemic hepatitis (e.g ... use assessment (e.g ... laboratory tests (e.g ... #Hepatology #AIH
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
inflammation (eg ... been reported (eg ... , AIH diagnosis ... of Hepatitis (eg ... #Hepatology
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