Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Differential Diagnosis ... Familial: Bartter syndrome ... and Gitelman syndrome ... #causes #nephrology ... #magnesium #low
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Hypomagnesemia - ... diarrhea / IBD Renal ... - Familial renal ... #Differential #Diagnosis ... #Low #Magnesium
Approach to Hypomagnesemia 

Fractional excretion of magnesium = (urine magnesium x serum creatinine)/ [0.7 (serum magnesium
Approach to Hypomagnesemia ... cells FEMg >4% = renal ... #differential #diagnosis ... #causes #nephrology ... #magnesium #low
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
- Differential Diagnosis ... Algorithm Extra-renal ... loss (Diarrhea) Renal ... #Differential #Diagnosis ... #nephrology
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Hypokalemia Differential Diagnosis ... Algorithm Low ... oral intake Renal ... Medication • Hypomagnesemia ... • Bartter's syndrome
Causes of Hypomagnesemia - Differential Diagnosis Algorithm
GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
- Differential Diagnosis ... Malabsorption RENAL ... • Gitelman's syndrome ... #Magnesium #Low ... #Differential #Diagnosis
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
hypokalemia and hypomagnesemia ... pump inhibitor - Renal ... Fanconi syndrome ... #differential #diagnosis ... #nephrology #Causes
Cancer agents and Electrolyte Disorders
 • Hypocalcemia: Cisplatin from Low Mg, Cetuximab- due to low Mg
Axitinib,
Ifosfamide - Fanconi syndrome ... Regorafenib • Hypomaqnesemia ... : Cisplatin- renal ... Ifosfamide - Fanconi syndrome ... #chemotherapy #diagnosis
Hypophosphatemia Diagnostic Algorithm
- GI Losses
- Redistribution
- 1° HPT
- 1° Renal PO4 wasting: Hereditary, TIO, Fanconi Syndrome,
Hypophosphatemia Diagnostic ... - 1° HPT - 1° Renal ... , TIO, Fanconi Syndrome ... Hypophosphatemia #phosphorus #low ... #differential #nephrology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Hypercalcemia, Hypermagnesemia ... Guillain-Barré syndrome ... Hypocalcemia, Hypomagnesemia ... #differential #diagnosis ... #table #neurology