Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Differential diagnosis of schistocytes / fragmentation hemolysis:
 β€’ Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... β€’ Severe B12 deficiency ... #schistocytes #differential ... #diagnosis #hematology ... #hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 β€’ Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... G6PD deficiency) ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 β€’ Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology Atlas
 β€’ Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
spherocytosis, Hemolytic ... , Pulmonary emboli ... Schistocytes - Hemolytic ... key #diagnosis #differential ... #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 β€’ Acute infection
 β€’ Solid organ
Thrombocytosis - Differential ... specifically: iron deficiency ... , hemolysis, hemorrhage ... Thrombocytosis #Differential ... Diagnosis #Causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
deficiencies: Iron deficiency ... Microangiopathic hemolytic ... cell anemia, G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Appearance of Liver Lesions on Various Imaging Modalities
 β€’ Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver Lesions ... Contrast #CT #MRI #POCUS ... #radiology #differential ... #diagnosis #comparison ... table #appearance #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Appearance of Liver Lesions ... Metastasis #Liver #Lesions ... CT #radiology #differential ... #diagnosis #comparison ... table #appearance #hepatology
Etiologies of Folate Deficiency
 β€’ Decreased dietary intake - uncommon in this era
 β€’ Increased requirements
Etiologies of Folate Deficiency ... pregnant have hemolytic ... develop folate deficiency ... #FolicAcid #differential ... #diagnosis #hematology