Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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9 results
Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
factors affecting toxicity ... Acetaminophen #APAP ... #metabolism #toxicity ... #Toxicology #Pathophysiology ... #Overdose
Glucagon: Bypassing Ξ²-Blockade

Glucagon pathophysiology and clinical applications in anaphylaxis and beta-blocker overdose

#Toxicology #Pharmacology #Pathophysiology #Glucagon #BetaBlocker
Ξ²-Blockade Glucagon pathophysiology ... and beta-blocker overdose ... #Toxicology # ... Pharmacology #Pathophysiology ... #BetaBlockade #Overdose
Acyclovir - Pharmacology Summary

 β€’ Mechanism of Action: Nucleoside analog - selectively inhibits viral replication of
Acyclovir - Pharmacology ... replication of HSV β€’ Antimicrobial ... Resistance β€’ Toxicity ... #Acyclovir #Pharmacology ... #InfectiousDiseases
Intravenous Lipid Emulsion (ILE) Therapy

ILE is a treatment for severe toxicity from local anesthetics. In addition,
treatment for severe toxicity ... life-threatening toxicity ... #ILE #Therapy #Toxicology ... #Management #Pharmacology ... #Overdose #intralipid
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
non-toxic route of APAP ... gets saturated in overdoses ... #Pathophys #Toxicology ... #NAC #APAP #NAcetylCysteine ... Acetaminophen #Toxicity
N-Acetylcysteine (NAC) restores hepatic glutathione!
Found to have 21-28% reduction in mortality for acetaminophen-induced hepatic failure
The earlier
concern for ANY overdose ... ) #Diagnosis #Toxicology ... Acetaminophen #Toxicity ... #APAP
Fomepizole for Acetaminophen Toxicity

 β€’ In cases where fomepizole and NAC were administered together, evidence has
Acetaminophen Toxicity ... recommended for massive APAP ... Acetaminophen #Toxicology ... #pharmacology #
CSF Penetration of Antimicrobials

Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
Penetration of Antimicrobials ... infections 3 overcome ... Penetration #CNS #Antimicrobials ... #InfectiousDiseases ... #Pharmacology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... the most severe overdoses ... evidence of marrow toxicity ... #Toxicity #Management ... #Pharmacology