Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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management diagnosis clinical dermatology differential rheumatology comparison skinrash pharmacology idsa skin anemia causes gastroenterology hemophagocytic hivaids infection lymphohistiocytosis microscopy opportunistic
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... can mimic common infections ... : • Infection ... rapidly, and empiric antibiotic ... #hematology
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
catheter-related bloodstream infection ... of metastatic infection ... Hemodynamically stable ... Hernodynamically stable ... after treatment
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
) Treatment Primary ... associated with infection ... or autoimmune disease ... for refractory disease ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
cold agglutin disease ... Mycoplasma pneumoniae infection ... Drugs (Beta lactam antibiotics ... spherocytosis) • Infections ... differential #diagnosis #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... megaloblastic anemia Treatment ... (transfusions, antibiotics ... diagnosis #management #treatment ... #hematology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
Non-HCV infectious ... neuropathy Treatment ... Specific anti-infectious ... with refractory disease ... Cryoglobulinemia #Vasculitis #Rheumatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
malnutrition, Antibiotics ... Malabsorption (e.g. celiac disease ... Advanced Liver Disease ... Deficiencies #Summary #table ... comparison #diagnosis #hematology
Conditions Associated With Hyperferritinemia DDx of extreme hyperferritinemia >10,000 Not just HLH - in fact, most common
10,000 Not just HLH ... Liver disease 3. ... Transfusion - Liver Disease ... - Malignancy—Hematologic ... - Primary HLH
Hordeolum vs Chalazion Hordeolum (Stye): • Location: Most commonly found at or near an eyelash follicle •
Cause: Bacterial infection ... , swelling • Treatment ... painless lump • Treatment ... Warm compresses, antibiotic ... Chalazion #Comparison #Table
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