The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology symptoms signs genetics geriatrics pharmacology 21hydroxylasedeficiency 21ohd alcohol alcoholusedisorder alzheimersdisease benzodiazepine bzd dementia endocrinology falls nightmares ophthalmology opiate opioid
Alcohol Use Disorder: Pathogenesis and Clinical Findings • Tolerance (reduced sensitivity to effects of EtOH) •
to effects of EtOH ... exacerbated by EtOH ... desire to use EtOH ... • Withdrawal ... Pathophysiology #Diagnosis
Falls: Pathogenesis and Complications Poly-pharmacy Disorders affecting movement and balance - Sensory deficits - Neuromuscular degeneration/Cerebrovascular disease -
Pathogenesis and Complications ... Lifestyle #Geriatrics ... pathophysiology #complications ... #diagnosis
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... pathophysiology #peds ... #pediatrics
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
resolve by 72 hours Complications ... pathophysiology #diagnosis ... symptoms #signs #peds ... #pediatrics
Opioid Withdrawal: Clinical Findings and Complications Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
Opioid Withdrawal ... Clinical Findings and Complications ... Note: Opioid withdrawal ... combined with withdrawal ... Pathophysiology #Diagnosis
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... endocrinology #peds ... #pediatrics
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Signs / Symptoms / Complications ... pathophysiology #geriatrics ... #diagnosis #signs
Alcohol Withdrawal: Clinical Findings and Complications The onset of alcohol withdrawal generally begins 6-24 hours after the
Alcohol Withdrawal ... Clinical Findings and Complications ... >2 days after EtOH ... Pathophysiology #Diagnosis ... Signs #Symptoms #EtOH
Benzodiazepine (BZD) withdrawal: clinical findings and complications • Activation of ACC and OFC -> Feelings of
Benzodiazepine (BZD) withdrawal ... clinical findings and complications ... Benzodiazepine #BZD #withdrawal ... pathophysiology #diagnosis
Retinopathy of Prematurity: Pathogenesis and clinical findings Increased metabolic demand of growing eye -> Excessive VEGF production ->
-> Neovascular complications ... #Prematurity #peds ... #pediatrics #pathophysiology
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