The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug reaction ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions ... #Types #Classification ... #Diagnosis #Definitions
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Gustilo-Anderson Classification ... GustiloAnderson #Classification ... Open #Fractures #Diagnosis ... Complications #MSK #Orthopedics
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
degranulation, leading ... antigen-surface complex, leading ... , leading to an ... #Types #Classification ... #Diagnosis #Definitions
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
other proteins leaking ... ischemia -> Venous beading ... Retinopathy #Diabetes #ophthalmology ... #diagnosis #complications
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
ligament substance leading ... ligament substance leading ... #Sports #MSK #orthopedics ... Grading #Grades #Diagnosis
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
• Avulsion or shearing ... Fractures #msk #diagnosis ... signs #symptoms #orthopedics
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification of ... PelvicRing #Fractures #Classification ... Grades #Grading #Orthopedics ... #MSK #diagnosis
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... > Inflammatory reaction ... #Fracture #Healing ... #Stages #Orthopedics ... pathophysiology #diagnosis