The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms lupus sle stages adhesivecapsulitis caudaequina disruptors erythematosus fracture frozenshoulder healing incontinence manifestations mixed mucocutaneous musculoskeletal orthopedics pagetsdisease
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... Signs / Symptoms / Complications ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
exposed areas -> Scaring ... with keratotic scaling ... hair follicles -> causes ... pathophysiology #diagnosis ... signs #symptoms #complications
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
a stroke that caused ... pathophysiology #diagnosis ... signs #stages #staging ... #msk
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Incr PVR if a complication ... SUI or UUI not caused ... Signs #Symptoms #Urology ... #Diagnosis
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... Abnormal Osteoclasts cause ... bone formation MSK ... pathophysiology #diagnosis ... signs #symptoms #complications
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
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