The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... loading Stress Fracture ... StressFractures #msk #orthopedics ... pathophysiology #symptoms
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... in elderly Causes ... #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... lateral hip Signs/Symptoms ... #msk #diagnosis ... pathophysiology #signs #symptoms ... #orthopedics
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
of Pelvic Ring Fractures ... Grade 2 - Rami fracture ... #PelvicRing #Fractures ... Grades #Grading #Orthopedics ... #MSK #diagnosis
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Open Fractures: ... Mechanisms, Clinical Features ... Classification #Open #Fractures ... #Diagnosis #Complications ... #MSK #Orthopedics
Central Retinal Vein Occlusion (CRVO): Pathogenesis and clinical findings

#CentralRetinalVein #Occlusion #CRVO #pathophysiology #ophthalmology #diagnosis #signs #symptoms
pathophysiology #ophthalmology ... #diagnosis #signs ... #symptoms
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... suicide Other Symptoms ... with psychotic features ... with psychotic features ... MoodDisorders #Diagnosis
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
hyalinization causes ... BRB breakdown causes ... pathophysiology #ophthalmology ... #diagnosis #signs ... #symptoms #complications
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Acne • Coarse features ... Overproduction #diagnosis ... #signs #symptoms
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... is thought to cause ... the Positive Symptoms ... is thought to cause ... pathophysiology #diagnosis