The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... gain Incr NE: Nausea ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Dizziness - Nausea ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis
Subjective Tinnitus: Pathogenesis and clinical findings
Subjective Tinnitus - Perceived sound with no acoustic stimulus, heard only
refers to sound caused ... #Tinnitus #Causes ... #pathophysiology ... #differential #diagnosis
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Systemic effect -> Nausea ... MoodStabilizers #Mechanism #SideEffects ... #Pathophysiology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
within GI and URT causes ... Maternal viremia causes ... Hematogenous spread causes ... evasion techniques cause ... peds #pediatrics #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
For pituitary masses ... Headaches • Nausea ... #Macroadenoma #SideEffects ... mnemonic #GLFTAP #pathophysiology
Septic Arthritis: Pathogenesis and clinical findings
Notes:
- Septic Arthritis is typically monoarticular & the knee is involved
involved in >50% of cases ... S.A. can also be caused ... SepticArthritis #pathophysiology ... #diagnosis
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... • Other rare causes ... Overproduction #diagnosis ... endocrinology #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Complications #pathophysiology ... signs #symptoms #diagnosis
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... antigens are the cause ... Allergy #Immunology #pathophysiology