The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology msk sideeffects antipsychotics avascularnecrosis complications erythematosus excess firstgeneration gh glftap growthhormone lupus macroadenoma masseffects mastoiditis mechanisms musculoskeletal otology overproduction
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Esp. humeral and femoral ... Myopathy (Also caused ... pathophysiology #signs ... #symptoms #diagnosis
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
of the Hip • Arthritis ... Slipped capital femoral ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... tolerance • Weight gain ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
A good mnemonic ... Signs / Symptoms ... dysfunction • Bitemporal ... #SideEffects #endocrinology ... #mnemonic #GLFTAP
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
Takayasu’s Arteritis ... , Incr risk of Acute ... #Takayasus #Arteritis ... #Vasculitis #Diagnosis ... #Signs #Symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... • Non-specific Acute-phase ... deviation, etc • Systemic ... Extra-articular signs ... #symptoms #diagnosis
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... portion of the temporal ... hearing loss, nausea ... pathophysiology #signs ... #symptoms #diagnosis
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
brain • Weight Gain ... VTA -> limbic system ... Extrapyramidal Symptoms ... , and/or limbs caused ... #pharmacology #diagnosis
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
blood supply & the femoral ... ) • Multiple causes ... affected) - Acute ... pathophysiology #diagnosis ... #signs #symptoms
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