The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs msk gh caudaequina causes endocin excess feedbackloop gait gravesdisease inflammatory jointdisease jointpain menstrualcycle ovariancycle overproduction pituitary syndrome trendelenburg
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
fraction • HTN #GrowthHormone ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... pathophysiology #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
• Large lumbar degenerative ... spine Signs / Symptoms ... pathophysiology #diagnosis ... #symptoms #signs
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Inflammatory and Degenerative ... ESR, RF, ANA) Degenerative ... #Inflammatory #Degenerative ... #Comparison #Versus ... JointDisease #JointPain #Diagnosis
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
around the hip • Degeneration ... pathophysiology #causes #symptoms ... #signs #diagnosis
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
follicle (others degenerate ... pathophysiology #comparison ... #endocrinology
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