The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms growthhormone pituitary urology acquired adhesivecapsulitis bonestrength bulimianervosa complications diabetic diabeticketoacidosis differential disorders dka dysfunction endocin erectile excess
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... Overproduction #diagnosis ... signs #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... GrowthHormone #GH ... #FeedbackLoop #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... Hyperprolactinemia • Diabetes ... #SideEffects #endocrinology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
trauma, iatrogenic, diabetes ... and rigidity Endocrinologic ... hyperlipidemia, diabetes ... (penile artery diameter ... Pathophysiology #Urology #Diagnosis
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... Neovascularization #Diabetic ... #Retinopathy #Diabetes ... ophthalmology #diagnosis
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... pathophysiology #endocrinology ... #diabetes
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
pathophysiology #endocin #endocrinology ... symptoms #signs #diagnosis
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
cystitis, UTI), diabetes ... Symptoms #Urology #Diagnosis
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
autoimmune disorders (diabetes ... pathophysiology #diagnosis
Acquired Disorders of Reduced Bone Strength: Pathogenesis • Hyperparathyroidism • Vitamin D deficiency • Malabsorption syndromes
• Smoking • Diabetes ... #differential #diagnosis
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