The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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geriatrics pituitary diagnosis genetics peds 21hydroxylasedeficiency 21ohd alzheimersdisease complications constipation dementia diabeticfoot diabeticketoacidosis dka erectile fecal gh glftap growthhormone incontinence
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
trauma, iatrogenic, diabetes ... and rigidity Endocrinologic ... hyperlipidemia, diabetes ... (penile artery diameter ... #Pathophysiology
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Prolactin #PRL #FeedbackLoop ... #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
GrowthHormone #GH #FeedbackLoop ... #endocrinology ... #pathophysiology
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Executive planning dysfunction ... concentration • Motor dysfunction ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... increasing cytogenetic dysfunction ... neuropathy => Diabetic ... a person with diabetes ... #DiabeticFoot #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Obesity -> Type 2 diabetes ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Hyperprolactinemia • Diabetes ... • Hypothalamic dysfunction ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Fecal Incontinence - Pathogenesis and Complications Continence mechanisms are impaired • Local neuronal damage • External and
Diabetes) • Altered ... #Incontinence #geriatrics ... #pathophysiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology ... #diabetes
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
#21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
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