The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology allergy diagnosis hypersensitivityreaction agammaglobulinemia antipsychotics bonetumors diabetes diabeticketoacidosis feedbackloop gh growthhormone malignant mechanisms oncogenesis oncology pharmacology pituitary psychiatry radiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... , body K+ is lost ... brain... thus, the body ... pathophysiology #endocrinology
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... metastasized to the bone ... • Metastatic bone
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
binds receptor on body ... the surfaces of body ... created on the body ... HypersensitivityReaction #Allergy #Immunology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... #FeedbackLoop #endocrinology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Abs persist in body ... HypersensitivityReaction #Allergy #Immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
cells in blood and bone ... pathophysiology #immunology
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Block action of DA ... action throughout body ... action throughout body
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
to synthesize DNA ... incorporating the new DNA ... pathophysiology #immunology
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