The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology signs symptoms anorexianervosa antipsychotics mechanisms pharmacology sideeffects bulimianervosa riskfactors bonetumors complications diabetes diabeticketoacidosis feedbackloop firstgeneration gh growthhormone malignant
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... , body K+ is lost ... brain... thus, the body ... pathophysiology #endocrinology
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... metastasized to the bone ... • Metastatic bone
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Block action of DA ... action throughout body ... action throughout body ... pharmacology #diagnosis #psychiatry
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Prevents excess DA ... and deficient DA ... pharmacology #diagnosis #psychiatry
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... #FeedbackLoop #endocrinology
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
ACh throughout body ... pharmacology #diagnosis #psychiatry
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
Osteoporosis - Low bone ... Emaciation: loss of body ... mortality rates of all psychiatric ... signs #symptoms #psychiatry
Bulimia Nervosa: Signs and Symptoms Associated Psychological / Behavioural Features • Feelings of shame, guilt and embarrassment
influenced by body ... signs #symptoms #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors Biological Risk Factors • Gender: F > M • Genetics: concordance
of ideal female body ... and very little body ... signs #symptoms #psychiatry
Bulimia Nervosa: Pathogenesis and Risk Factors Biological Risk Factors • Gender: F > M • Genetics: Some
of ideal female body ... and very little body ... Childhood obesity (body ... signs #symptoms #psychiatry
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