The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis sideeffects antipsychotics growthhormone menstrualcycle ovariancycle pharmacology pituitary psychiatry comparison diabetes diabeticketoacidosis dysfunction erectile excess feedbackloop follicularphase glftap immunology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... GrowthHormone #GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... GrowthHormone #GH ... signs #symptoms #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Treating DKA: 1) ... DiabeticKetoacidosis #DKA ... pathophysiology #endocrinology
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Antipsychotics: Mechanisms ... Block action of DA ... Cardio-metabolic effects - Mechanism ... SecondGeneration #Mechanisms
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Antipsychotics: Mechanisms ... Prevents excess DA ... and deficient DA ... ThirdGeneration #Mechanisms
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... #SideEffects #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
continue growing (mechanism ... growth (this is one mechanism ... FollicularPhase #endocrinology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
disorder -> Possible mechanisms ... and rigidity Endocrinologic
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
puberty (unclear mechanisms ... pathophysiology #comparison #endocrinology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections: Mechanisms ... to synthesize DNA ... incorporating the new DNA
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