The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs symptoms growthhormone pituitary acute caudaequina causes complications erectile excess feedbackloop gait glftap injury macroadenoma masseffects mnemonic neurology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... GrowthHormone #GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... GrowthHormone #GH ... signs #symptoms #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
Erectile Dysfunction ... Pathogenesis Erectile Dysfunction ... Psychogenic Erectile Dysfunction ... and rigidity Endocrinologic ... Erectile Dysfunction
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Upper Extremity Dysfunction ... deficiencies -> Sphincter dysfunction ... signs #symptoms #msk
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
bladder/bowel dysfunction ... CaudaEquina #Syndrome #MSK
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Compensatory muscular dysfunction ... signs #diagnosis #msk
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
bone formation MSK ... causes middle ear dysfunction
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