The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis menstrualcycle ovariancycle peds geriatrics symptoms signs pituitary dementia feedbackloop genetics growthhormone uterinecycle 21hydroxylasedeficiency 21ohd alzheimersdisease childhood comparison complications constipation
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... GH excess after ... signs #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... #FeedbackLoop #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Falls: Pathogenesis and Complications Poly-pharmacy Disorders affecting movement and balance - Sensory deficits - Neuromuscular degeneration/Cerebrovascular disease -
Lifestyle #Geriatrics ... #Falls #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Hyperthyroidism #endocrinology ... #pathophysiology
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
GravesDisease #pathophysiology ... #endocin #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
#21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
#FeedbackLoop #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
#OvarianCycle #pathophysiology ... #menstruation #endocrinology
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome #genetics #pathophysiology ... #peds #pediatrics
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