The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis msk sideeffects 21ohd alzheimersdisease caudaequina complications dementia diabetes diabeticketoacidosis dka excess gait genetics geriatrics gh glftap growthhormone inhibitors
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... / Symptoms / Complications ... Executive planning dysfunction ... geriatrics #diagnosis #signs ... #symptoms
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... a scrotum #21HydroxylaseDeficiency ... pathophysiology #genetics #endocrinology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... Vertigo, Sexual Dysfunction ... gain Incr NE: Nausea ... Psychiatry #Diagnosis #Signs ... #Symptoms
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... lumbar spine Signs ... / Symptoms / Complications ... bladder/bowel dysfunction ... #signs
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
For pituitary masses ... Signs / Symptoms ... Headaches • Nausea ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
out of cells may cause ... anion gap until it closes ... Signs/Symptoms/Complications ... Abdominal pain, nausea ... pathophysiology #endocrinology
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Compensatory muscular dysfunction ... pathophysiology #causes ... #symptoms #signs
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... Skull expansion causes ... middle ear dysfunction ... pathophysiology #diagnosis #signs ... #symptoms #complications
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