The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis gh growthhormone msk ovariancycle psychiatry sideeffects 21hydroxylasedeficiency 21ohd alzheimersdisease anxiety behavioraldisorder caudaequina comparison complications dementia diabetes diabeticketoacidosis dka
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
masses of all sizes ... Signs / Symptoms ... Headaches • Nausea ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
on the anterior pituitary ... and release LH causes ... for clarity) #MenstrualCycle ... pathophysiology #Ovulation #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... / Symptoms / Complications ... Executive planning dysfunction ... geriatrics #diagnosis #signs ... #symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... Vertigo, Sexual Dysfunction ... gain Incr NE: Nausea ... Psychiatry #Diagnosis #Signs ... #Symptoms
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... lumbar spine Signs ... / Symptoms / Complications ... bladder/bowel dysfunction ... #signs
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
out of cells may cause ... anion gap until it closes ... Signs/Symptoms/Complications ... Abdominal pain, nausea ... pathophysiology #endocrinology
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Compensatory muscular dysfunction ... pathophysiology #causes ... #symptoms #signs
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