The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... #pathophysiology ... signs #symptoms #msk ... #orthopedics #neurology
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Clinical Features and Complications ... Typically "inside out" injury ... Fractures #Diagnosis #Complications ... #MSK #Orthopedics
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Avulsion or shearing injury ... Signs/Symptoms/Complications ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... signs #symptoms #orthopedics
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
- Type 1 or 2 injury ... Grades #Grading #Orthopedics ... #MSK #diagnosis ... #complications ... #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Signs/Symptoms/Complications ... #genetics #pathophysiology ... #peds #pediatrics
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
most commonly injured ... (uncommonly injured ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading ... Grades #Diagnosis #pathophysiology
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
Signs/Symptoms/Complications ... signs #symptoms #pathophysiology ... #msk #orthopedics
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Signs / Symptoms / Complications ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics