The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
StressDisorder #PTSD #BehavioralDisorder ... Pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... to 25 for new diagnosis ... AttentionDeficitHyperactiveDisorder #ADHD #BehavioralDisorder ... #symptoms #signs ... #psychiatry #criteria
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
joint => Force exceeds ... to glenoid -> Acute ... #Dislocation #Diagnosis ... #signs #symptoms
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
PanicDisorder #Anxiety #BehavioralDisorder ... Pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
• Non-specific Acute-phase ... joint capsule exceeds ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis
Narcissistic Personality Disorder: Pathogenesis and Clinical Findings
 • Arrogant, Haughty Behaviors or Attitude - Often display
- Entitlement, Excess ... PersonalityDisorder #Diagnosis ... #Psychiatry #Criteria ... #Signs #Symptoms
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
SocialAnxiety #BehavioralDisorder ... Pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
- Lethargy or Excess ... mortality rates of all psychiatric ... pathophysiology #diagnosis ... #signs #symptoms ... #psychiatry