The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis genetics gh growthhormone pediatrics peds pituitary urinarytractinfection 21hydroxylasedeficiency 21ohd adhesivecapsulitis bulimianervosa diabeticketoacidosis dka endocin excess feedbackloop frozenshoulder glftap
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... /Symptoms: - Pretibial ... pathophysiology #endocin #endocrinology ... #symptoms #signs
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... Signs/Symptoms/Complications ... pathophysiology #endocrinology ... #diabetes
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Signs/Symptoms: ... Hyperthyroidism #endocrinology
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings - Predisposing Factors: Immunocompromised state, diabetes, elderly, female
Immunocompromised state, diabetes ... epithelium and causing symptoms ... Signs/Symptoms ... Pathophysiology #Signs ... #Symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... /Symptoms/Complications ... Obesity -> Type 2 diabetes
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Signs / Symptoms ... Hyperprolactinemia • Diabetes ... #SideEffects #endocrinology
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings Predisposing Factors: - Immunocompromised, Diabetes, - Elderly, Female
Immunocompromised, Diabetes ... Pathophysiology #Signs ... #Symptoms
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Overproduction #diagnosis #signs ... #symptoms #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology
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