The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... Hormone (GH) Growth ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... GH excess after ... signs #symptoms #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
sudden +++ positive feedback ... negative to positive feedback ... #OvarianCycle #pathophysiology ... #Ovulation #endocrinology
Feedback Loop: Prolactin (PRL)
 • PRL levels exhibit diurnal, menstrual, and age-related variation
 • TRH has
Feedback Loop: Prolactin ... #FeedbackLoop #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis
Estrogen, when released:
 • Negatively feeds back on the hypothalamus and
MenstrualCycle #pathophysiology ... HypothalamicPituitary #endocrinology ... #feedback
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
following order; GH ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
#UterineCycle #MenstrualCycle ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
Menstrual Cycle Physiology: the Uterine Cycle
The endometrium has receptors for ovarian hormones! Changes in structure and
#OvarianCycle #pathophysiology ... #UterineCycle # ... endocrinology